A woman (Herring) is abandoned on Mulholland Drive, following a car accident, suffering from amnesia.
She makes her way to an apartment where she meets an aspiring actress (Watts) who helps her put the pieces of her life back together.
Elsewhere, other stories and characters weave into this ensemble piece, including a director (Theroux) with mobster problems, and a man whose dream comes true..
Michael J. Anderson plays a studio executive; Ann Miller plays the manager of the apartment complex.